Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trialArticle Published on 2022-11-032022-11-16 Journal: Journal of Translational Medicine [Category] 비임상, [키워드] 1:1 Administered administration adverse event age Analysis animal model Anti-inflammatory assigned baseline Borg change changes in Chronic diseases clinical trial clinically COVID COVID pneumonia COVID-19 defined Diagnosis discharged double-blind Dyspnea Effect effective Efficacy Endpoint enrolled evaluated female female gender FEV first symptom FVC impairment increase in indicated Infection initial LLC lung damage Lung fibrosis Lung function Lungs mMRC moderate NCT04527354 offer past medical history Patient patients pharmacological treatment Placebo placebo group placebo-controlled clinical trial placebo-controlled trial Post-COVID rehabilitation predicted Prevent Primary outcome proportion pulmonary dysfunction pulmonary fibrosis Pulmonary function questionnaire Randomized Randomly reduction in Registered rehabilitation risk factor Russia SARS-CoV-2 secondary shown significant decrease significant difference stratified Support Symptoms Tolerability Treamid. Treatment Trial was done women [DOI] 10.1186/s12967-022-03660-9 PMC 바로가기
Accuracy of quality of life questionnaire as a diagnostic tool for SARS-CoV-2 pulmonary sequelaeArticle Published on 2022-10-142022-11-16 Journal: Medicina clínica [Category] COVID19(2023년), SARS, 치료기술, [키워드] age alteration alterations AUC Cardiopulmonary Covid persistente COVID-19 CPET Cuestionario de calidad de vida SF-12 detect diagnostic domain English female first positive follow-up study functional Healthcare system hospital discharge Hospitalization identify Long Long COVID maximum oxygen consumption media Patient PCR performed physical predicted primer Prospective prospectivo Prueba de esfuerzo cardiopulmonar Pruebas funcionales respiratorias pulmonary Pulmonary function Pulmonary function test Quality of life questionnaire reduced SARS-CoV-2 Sensitivity and specificity SF-12 quality of life questionnaire. significantly Spanish survivor Symptom Symptoms utility [DOI] 10.1016/j.medcli.2022.02.007 PMC 바로가기
Changes in Care during the COVID-19 Pandemic for People with Cystic FibrosisArticle Published on 2022-10-012022-11-16 Journal: Annals of the American Thoracic Society [Category] 변종, [키워드] 95% CI 95% confidence interval age Ambulatory care BMI body mass index calculated Care change changed changes in children coronavirus disease COVID-19 COVID-19 pandemic Cystic cystic fibrosis effective eligible enrolled expiratory FEV foundation Lung function no difference Paired t test pandemic predicted proportion pulmonary exacerbation Pulmonary function pulmonary function. registry risk severe disease the mean transitioned transmembrane Volume [DOI] 10.1513/AnnalsATS.202105-532OC PMC 바로가기
Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung diseaseClinical Trial Published on 2022-07-232022-10-05 Journal: Orphanet Journal of Rare Diseases [Category] COVID19(2023년), SARS, 임상, [키워드] absence adverse event age all subject approval ARMS calculated chILD. childhood children Controlled trial double-blind effect size Endpoint evaluated four subject groups HCQ Health Hydroxychloroquine identify Interstitial lung disease Interstitial lung diseases lack lung Lung function multicentre Munich not differ not different offered outcome Oxygenation participated phase 2 trial Placebo placebo-controlled primary endpoint Pulmonary function Quality of life Randomized randomized-controlled trial Registered Registration respiratory rate Respiratory Support secondary study population subject Treatment treatment effects treatment period Trial university were given Withdrawal [DOI] 10.1186/s13023-022-02399-2 PMC 바로가기 [Article Type] Clinical Trial
A telerehabilitation programme in post-discharge COVID-19 patients (TERECO): a randomised controlled trialRandomized Controlled Trial Published on 2022-07-012022-10-05 Journal: Thorax [Category] 임상, [키워드] 1:1 95% CI aerobic Block randomisation China COVID-19 COVID-19 patient demonstrated Dyspnoea Effect Exercise capacity Follow-up form greater hospital hospitalised increase Jiangsu lower limb muscle Lung function maximum voluntary ventilation outcome physical Pulmonary function pulmonary rehabilitation pulmonary rehabilitation. Quality of life randomised randomised controlled trial rehabilitation secondary survivor Thoracic treatment effect Trial walking distance were assessed [DOI] 10.1136/thoraxjnl-2021-217382 PMC 바로가기 [Article Type] Randomized Controlled Trial
Effect of modified Total Body Recumbent Stepper training on exercise capacity and thioredoxin in COPD: a randomized clinical trial Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] acute exacerbation alleviate benefit Body Borg chronic obstructive control group COPD Dyspnoea Effect exercise Exercise capacity exercise intolerance exhibited Follow-up groups Guidance increase in indication Intervention mechanism mMRC mRNA expression no difference oxidative stress parameter Patient patients Protein pulmonary disease Pulmonary function pulmonary rehabilitation randomized clinical trial randomly divided reduce reduced rehabilitation significantly increased Spinal cord injury Stepper stroke Symptom Total undergo walking distance [DOI] 10.1038/s41598-022-15466-2 [Article Type] Research
Chronic lung lesions in COVID-19 survivors: predictive clinical modelCOVID-19 생존자의 만성 폐 병변: 예측 임상 모델Article Published on 2022-06-132022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 치료기술, [키워드] Abnormalities abnormality architectural distortion automated Brazil bronchiectasis build Chest Chest CT chest imaging chest X-ray chronic Complete country COVID-19 COVID-19 infection CXR detect Dyspnoea e parameters Early detection eligible forced vital capacity FVC Ground-glass opacities hospital hospital discharge hospitalised joint lung lung lesion lung lesions Medical Research Council mMRC outcome oximetry parameter parenchymal Patient Predictive prospective cohort study protocol Pulmonary function pulmonary involvement pulmonary lesion pulmonary lesions respiratory medicine (see thoracic medicine). reticulation RT-PCR SARS-COV-2 infection SARS-CoV-2-infected patient sensitivity specificity spirometry survivor Thoracic traction bronchiectasis vital capacity were used [DOI] 10.1136/bmjopen-2021-059110 PMC 바로가기 [Article Type] Article
Re-opening the pediatric pulmonary function laboratory during the ongoing COVID-19 pandemicReview article Published on 2022-06-012022-10-05 Journal: Paediatric respiratory reviews [Category] COVID19(2023년), SARS, 변종, [키워드] aerosol Air exchange rate concerning COVID-19 pandemic International Laboratory limit Lung function testing Patient pediatric Personal protective equipment provide Pulmonary function Pulmonary function testing recommendation risk [DOI] 10.1016/j.prrv.2022.01.001 [Article Type] Review article
Respiratory dysfunction three months after severe COVID-19 is associated with gut microbiota alterations심각한 COVID-19 3개월 후 호흡기 기능 장애는 장내 미생물 변화와 관련이 있습니다Article Published on 2022-06-012022-09-11 Journal: Journal of internal medicine [Category] COVID19(2023년), SARS, 임상, [키워드] 16S rRNA 16S rRNA gene alteration analysis analyzed Bacterial carbon monoxide collected coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 patient defined diffusing diffusing capacity disease severity dysfunction elevated Evidence fibrosis FIVE Follow-up gastrointestinal tract Gut gut microbiota gut microbiota composition gut-lung axis Hospital admission Hospitalization Hypothesis Inflammation investigated involved kPa LBP limit lipopolysaccharide low-grade inflammation lung Lungs marker Microbiome microbiota P/F ratio Patient plasma Protein pulmonary dysfunction Pulmonary function pulmonary function. Rectal swabs reduced remained respiratory Respiratory failure respiratory infection rRNA SARS-CoV-2 Sequencing severe COVID-19 Swab the disease Trial was collected was reduced [DOI] 10.1111/joim.13458 PMC 바로가기 [Article Type] Article